With the development of the biopharmaceutical industry and the increase in protein-based drug production, the capacity of chromatography and ultra-filtration systems in downstream purification is increasing annually. This leads to a higher demand for buffer solutions. In traditional batch preparation, the actual process is often time consuming, requiring bulky holding vessels which occupy a large floor area in the facility.Furthermore, the process requires a significant amount of CIP cleaning agents and cleaning water.
Inline conditioning is a newly rapid-developing technology, that overcomes the shortcomings of traditional batch preparation of buffer solutions. Inline systems have therefore been widely adopted in the downstream processing of many biopharmaceutical products, including monoclonal antibodies, vaccines, antibiotics, insulin, recombinant proteins as well as blood products.
Inline conditioning / dilution systems optimize the method which is used to prepare the buffer solutions, reduce the footprint of preparation and storage area, cut the expenses of daily maintenance and cleanliness validation as well as smooth scaleup, preparation and production.
• Reduce fixed investment and investment cost for expansion
• Save labor costs for operation and maintenance
• Reduce dosing time
• High precision preparation, conductivity ±0.5 ms/cm, pH value within ±0.2
• Stabilization within 2 min